diff --git a/src/ctl.c b/src/ctl.c
index 42ded601..8717c96d 100644
--- a/src/ctl.c
+++ b/src/ctl.c
@@ -2337,7 +2337,7 @@ thread_prof_name_ctl(tsd_t *tsd, const size_t *mib,
     size_t newlen) {
 	int ret;
 
-	if (!config_prof) {
+	if (!config_prof || !opt_prof) {
 		return ENOENT;
 	}
 
@@ -2374,8 +2374,12 @@ thread_prof_active_ctl(tsd_t *tsd, const size_t *mib,
 		return ENOENT;
 	}
 
-	oldval = prof_thread_active_get(tsd);
+	oldval = opt_prof ? prof_thread_active_get(tsd) : false;
 	if (newp != NULL) {
+		if (!opt_prof) {
+			ret = ENOENT;
+			goto label_return;
+		}
 		if (newlen != sizeof(bool)) {
 			ret = EINVAL;
 			goto label_return;
@@ -3128,6 +3132,10 @@ prof_thread_active_init_ctl(tsd_t *tsd, const size_t *mib,
 	}
 
 	if (newp != NULL) {
+		if (!opt_prof) {
+			ret = ENOENT;
+			goto label_return;
+		}
 		if (newlen != sizeof(bool)) {
 			ret = EINVAL;
 			goto label_return;
@@ -3135,7 +3143,8 @@ prof_thread_active_init_ctl(tsd_t *tsd, const size_t *mib,
 		oldval = prof_thread_active_init_set(tsd_tsdn(tsd),
 		    *(bool *)newp);
 	} else {
-		oldval = prof_thread_active_init_get(tsd_tsdn(tsd));
+		oldval = opt_prof ? prof_thread_active_init_get(tsd_tsdn(tsd)) :
+		    false;
 	}
 	READ(oldval, bool);
 
@@ -3161,13 +3170,19 @@ prof_active_ctl(tsd_t *tsd, const size_t *mib, size_t miblen,
 			goto label_return;
 		}
 		bool val = *(bool *)newp;
-		if (!opt_prof && val) {
-			ret = ENOENT;
-			goto label_return;
+		if (!opt_prof) {
+			if (val) {
+				ret = ENOENT;
+				goto label_return;
+			} else {
+				/* No change needed (already off). */
+				oldval = false;
+			}
+		} else {
+			oldval = prof_active_set(tsd_tsdn(tsd), val);
 		}
-		oldval = prof_active_set(tsd_tsdn(tsd), val);
 	} else {
-		oldval = prof_active_get(tsd_tsdn(tsd));
+		oldval = opt_prof ? prof_active_get(tsd_tsdn(tsd)) : false;
 	}
 	READ(oldval, bool);
 
@@ -3182,7 +3197,7 @@ prof_dump_ctl(tsd_t *tsd, const size_t *mib, size_t miblen,
 	int ret;
 	const char *filename = NULL;
 
-	if (!config_prof) {
+	if (!config_prof || !opt_prof) {
 		return ENOENT;
 	}
 
@@ -3210,13 +3225,17 @@ prof_gdump_ctl(tsd_t *tsd, const size_t *mib, size_t miblen,
 	}
 
 	if (newp != NULL) {
+		if (!opt_prof) {
+			ret = ENOENT;
+			goto label_return;
+		}
 		if (newlen != sizeof(bool)) {
 			ret = EINVAL;
 			goto label_return;
 		}
 		oldval = prof_gdump_set(tsd_tsdn(tsd), *(bool *)newp);
 	} else {
-		oldval = prof_gdump_get(tsd_tsdn(tsd));
+		oldval = opt_prof ? prof_gdump_get(tsd_tsdn(tsd)) : false;
 	}
 	READ(oldval, bool);
 
@@ -3231,7 +3250,7 @@ prof_prefix_ctl(tsd_t *tsd, const size_t *mib, size_t miblen,
 	int ret;
 	const char *prefix = NULL;
 
-	if (!config_prof) {
+	if (!config_prof || !opt_prof) {
 		return ENOENT;
 	}
 
@@ -3251,7 +3270,7 @@ prof_reset_ctl(tsd_t *tsd, const size_t *mib, size_t miblen,
 	int ret;
 	size_t lg_sample = lg_prof_sample;
 
-	if (!config_prof) {
+	if (!config_prof || !opt_prof) {
 		return ENOENT;
 	}
 
@@ -3278,7 +3297,7 @@ prof_log_start_ctl(tsd_t *tsd, const size_t *mib, size_t miblen, void *oldp,
 
 	const char *filename = NULL;
 
-	if (!config_prof) {
+	if (!config_prof || !opt_prof) {
 		return ENOENT;
 	}
 
@@ -3298,7 +3317,7 @@ label_return:
 static int
 prof_log_stop_ctl(tsd_t *tsd, const size_t *mib, size_t miblen, void *oldp,
     size_t *oldlenp, void *newp, size_t newlen) {
-	if (!config_prof) {
+	if (!config_prof || !opt_prof) {
 		return ENOENT;
 	}
 
diff --git a/src/prof.c b/src/prof.c
index 0f1f7a71..67a7f71a 100644
--- a/src/prof.c
+++ b/src/prof.c
@@ -554,72 +554,65 @@ bool
 prof_boot2(tsd_t *tsd, base_t *base) {
 	cassert(config_prof);
 
-	if (opt_prof) {
-		unsigned i;
+	/*
+	 * Initialize the global mutexes unconditionally to maintain correct
+	 * stats when opt_prof is false.
+	 */
+	if (malloc_mutex_init(&prof_active_mtx, "prof_active",
+	    WITNESS_RANK_PROF_ACTIVE, malloc_mutex_rank_exclusive)) {
+		return true;
+	}
+	if (malloc_mutex_init(&prof_gdump_mtx, "prof_gdump",
+	    WITNESS_RANK_PROF_GDUMP, malloc_mutex_rank_exclusive)) {
+		return true;
+	}
+	if (malloc_mutex_init(&prof_thread_active_init_mtx,
+	    "prof_thread_active_init", WITNESS_RANK_PROF_THREAD_ACTIVE_INIT,
+	    malloc_mutex_rank_exclusive)) {
+		return true;
+	}
+	if (malloc_mutex_init(&bt2gctx_mtx, "prof_bt2gctx",
+	    WITNESS_RANK_PROF_BT2GCTX, malloc_mutex_rank_exclusive)) {
+		return true;
+	}
+	if (malloc_mutex_init(&tdatas_mtx, "prof_tdatas",
+	    WITNESS_RANK_PROF_TDATAS, malloc_mutex_rank_exclusive)) {
+		return true;
+	}
+	if (malloc_mutex_init(&next_thr_uid_mtx, "prof_next_thr_uid",
+	    WITNESS_RANK_PROF_NEXT_THR_UID, malloc_mutex_rank_exclusive)) {
+		return true;
+	}
+	if (malloc_mutex_init(&prof_stats_mtx, "prof_stats",
+	    WITNESS_RANK_PROF_STATS, malloc_mutex_rank_exclusive)) {
+		return true;
+	}
+	if (malloc_mutex_init(&prof_dump_filename_mtx,
+	    "prof_dump_filename", WITNESS_RANK_PROF_DUMP_FILENAME,
+	    malloc_mutex_rank_exclusive)) {
+		return true;
+	}
+	if (malloc_mutex_init(&prof_dump_mtx, "prof_dump",
+	    WITNESS_RANK_PROF_DUMP, malloc_mutex_rank_exclusive)) {
+		return true;
+	}
 
+	if (opt_prof) {
 		lg_prof_sample = opt_lg_prof_sample;
 		prof_unbias_map_init();
-
 		prof_active = opt_prof_active;
-		if (malloc_mutex_init(&prof_active_mtx, "prof_active",
-		    WITNESS_RANK_PROF_ACTIVE, malloc_mutex_rank_exclusive)) {
-			return true;
-		}
-
 		prof_gdump_val = opt_prof_gdump;
-		if (malloc_mutex_init(&prof_gdump_mtx, "prof_gdump",
-		    WITNESS_RANK_PROF_GDUMP, malloc_mutex_rank_exclusive)) {
-			return true;
-		}
-
 		prof_thread_active_init = opt_prof_thread_active_init;
-		if (malloc_mutex_init(&prof_thread_active_init_mtx,
-		    "prof_thread_active_init",
-		    WITNESS_RANK_PROF_THREAD_ACTIVE_INIT,
-		    malloc_mutex_rank_exclusive)) {
-			return true;
-		}
 
 		if (prof_data_init(tsd)) {
 			return true;
 		}
 
-		if (malloc_mutex_init(&bt2gctx_mtx, "prof_bt2gctx",
-		    WITNESS_RANK_PROF_BT2GCTX, malloc_mutex_rank_exclusive)) {
-			return true;
-		}
-
-		if (malloc_mutex_init(&tdatas_mtx, "prof_tdatas",
-		    WITNESS_RANK_PROF_TDATAS, malloc_mutex_rank_exclusive)) {
-			return true;
-		}
-
 		next_thr_uid = 0;
-		if (malloc_mutex_init(&next_thr_uid_mtx, "prof_next_thr_uid",
-		    WITNESS_RANK_PROF_NEXT_THR_UID,
-		    malloc_mutex_rank_exclusive)) {
-			return true;
-		}
-
-		if (malloc_mutex_init(&prof_stats_mtx, "prof_stats",
-		    WITNESS_RANK_PROF_STATS, malloc_mutex_rank_exclusive)) {
-			return true;
-		}
-
 		if (prof_idump_accum_init()) {
 			return true;
 		}
 
-		if (malloc_mutex_init(&prof_dump_filename_mtx,
-		    "prof_dump_filename", WITNESS_RANK_PROF_DUMP_FILENAME,
-		    malloc_mutex_rank_exclusive)) {
-			return true;
-		}
-		if (malloc_mutex_init(&prof_dump_mtx, "prof_dump",
-		    WITNESS_RANK_PROF_DUMP, malloc_mutex_rank_exclusive)) {
-			return true;
-		}
-
 		if (opt_prof_final && opt_prof_prefix[0] != '\0' &&
 		    atexit(prof_fdump) != 0) {
 			malloc_write("<jemalloc>: Error in atexit()\n");
@@ -643,7 +636,7 @@ prof_boot2(tsd_t *tsd, base_t *base) {
 		if (gctx_locks == NULL) {
 			return true;
 		}
-		for (i = 0; i < PROF_NCTX_LOCKS; i++) {
+		for (unsigned i = 0; i < PROF_NCTX_LOCKS; i++) {
 			if (malloc_mutex_init(&gctx_locks[i], "prof_gctx",
 			    WITNESS_RANK_PROF_GCTX,
 			    malloc_mutex_rank_exclusive)) {
@@ -656,7 +649,7 @@ prof_boot2(tsd_t *tsd, base_t *base) {
 		if (tdata_locks == NULL) {
 			return true;
 		}
-		for (i = 0; i < PROF_NTDATA_LOCKS; i++) {
+		for (unsigned i = 0; i < PROF_NTDATA_LOCKS; i++) {
 			if (malloc_mutex_init(&tdata_locks[i], "prof_tdata",
 			    WITNESS_RANK_PROF_TDATA,
 			    malloc_mutex_rank_exclusive)) {
diff --git a/test/unit/mallctl.c b/test/unit/mallctl.c
index e9e0feb6..5cba0837 100644
--- a/test/unit/mallctl.c
+++ b/test/unit/mallctl.c
@@ -914,7 +914,7 @@ TEST_BEGIN(test_prof_active) {
 	old = true;
 	expect_d_eq(mallctl("prof.active", &old, &len, &active, len), ENOENT,
 	    "Setting prof_active to true should fail when opt_prof is off");
-	expect_true(old, "old valud should not be touched when mallctl fails");
+	expect_true(old, "old value should not be touched when mallctl fails");
 	active = false;
 	expect_d_eq(mallctl("prof.active", NULL, NULL, &active, len), 0,
 	    "Setting prof_active to false should succeed when opt_prof is off");