diff --git a/include/jemalloc/internal/jemalloc_internal.h.in b/include/jemalloc/internal/jemalloc_internal.h.in
index fdc8fef9..e7ace7d8 100644
--- a/include/jemalloc/internal/jemalloc_internal.h.in
+++ b/include/jemalloc/internal/jemalloc_internal.h.in
@@ -337,7 +337,7 @@ typedef unsigned szind_t;
 
 /* Return the nearest aligned address at or below a. */
 #define	ALIGNMENT_ADDR2BASE(a, alignment)				\
-	((void *)((uintptr_t)(a) & (-(alignment))))
+	((void *)((uintptr_t)(a) & ((~(alignment)) + 1)))
 
 /* Return the offset between a and the nearest aligned address at or below a. */
 #define	ALIGNMENT_ADDR2OFFSET(a, alignment)				\
@@ -345,7 +345,7 @@ typedef unsigned szind_t;
 
 /* Return the smallest alignment multiple that is >= s. */
 #define	ALIGNMENT_CEILING(s, alignment)					\
-	(((s) + (alignment - 1)) & (-(alignment)))
+	(((s) + (alignment - 1)) & ((~(alignment)) + 1))
 
 /* Declare a variable-length array. */
 #if __STDC_VERSION__ < 199901L